pEVL: A Linear Plasmid for Generating mRNA IVT Templates With Extended Encoded Poly(A) Sequences
نویسندگان
چکیده
منابع مشابه
pEVL: A Linear Plasmid for Generating mRNA IVT Templates With Extended Encoded Poly(A) Sequences
Increasing demand for large-scale synthesis of in vitro transcribed (IVT) mRNA is being driven by the increasing use of mRNA for transient gene expression in cell engineering and therapeutic applications. An important determinant of IVT mRNA potency is the 3' polyadenosine (poly(A)) tail, the length of which correlates with translational efficiency. However, present methods for generation of IV...
متن کاملa new type-ii fuzzy logic based controller for non-linear dynamical systems with application to 3-psp parallel robot
abstract type-ii fuzzy logic has shown its superiority over traditional fuzzy logic when dealing with uncertainty. type-ii fuzzy logic controllers are however newer and more promising approaches that have been recently applied to various fields due to their significant contribution especially when the noise (as an important instance of uncertainty) emerges. during the design of type- i fuz...
15 صفحه اولNebulisation of IVT mRNA Complexes for Intrapulmonary Administration
During the last years the potential role of in vitro transcribed (IVT) mRNA as a vehicle to deliver genetic information has come into focus. IVT mRNA could be used for anti-cancer therapies, vaccination purposes, generation of pluripotent stem cells and also for genome engineering or protein replacement. However, the administration of IVT mRNA into the target organ is still challenging. The lun...
متن کاملLinear Cellular Automata as Discrete Models for Generating Cryptographic Sequences
This work shows that a wide class of cryptographic sequences, the so-called interleaved sequences, can be generated by means of linear multiplicative polynomial cellular automata. In fact, this type of onedimensional linear 90/150 cellular automata can be devised as generators of pseudo-random sequences. Moreover, these linear automata generate all the solutions of a type of difference equation...
متن کاملPolya Sequences, Toeplitz Kernels and Gap Theorems
A separated sequence Λ on the real line is called a Polya sequence if any entire function of zero exponential type bounded on Λ is constant. In this paper we solve the problem by Polya and Levinson that asks for a description of Polya sets. We also show that the Polya-Levinson problem is equivalent to a version of the so-called Beurling gap problem on Fourier transforms of measures. The solutio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Therapy - Nucleic Acids
سال: 2016
ISSN: 2162-2531
DOI: 10.1038/mtna.2016.21